Structural Modification for Antitumor Nitrogenous Steroid

分类： 化学 >> 物理化学 提交时间： 2017-11-05 合作期刊: 《结构化学》

XIE Tian-Peng YANG Kang ZHANG Li-Zhi CHEN De-Sheng ZOU Kun HUANG Nian-Yu

摘要： Natural steroids have been showing notable cytotoxic activities, which are quite interesting lead compounds for the development of anticancer drug including estramustine and prednimustine. Considering that these semi-synthetic molecules are nitrogen mustard functionalized steroidal derivatives, the present review is focused on the methodologies of introducing nitrogen atom or nitrogen-containing heterocycles on A～D rings or side chains of steroids, and analysis of the structure-activity relationship (SAR) for these man-made cytotoxic steroids

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